Mesenchymal stem cells (MSCs) have been shown to modulate the immune response by interacting with various immune cells, including T cells, which are involved in the immune response against Lyme disease. MSCs can indirectly enhance the activity of T cells by producing various cytokines and other signalling molecules that promote T-cell activation, proliferation, and differentiation.
In the context of Lyme disease, T cells play an important role in the immune response against the bacterium Borrelia burgdorferi. T cells are responsible for recognizing and selectively targeting the bacteria, and also play a role in promoting inflammation and tissue damage in the affected tissues. However, when the immune response becomes dysregulated, as in chronic Lyme disease, this can lead to persistent inflammation and tissue damage.
By modulating the immune response, MSCs may help to promote a more balanced and targeted response against Lyme disease, by enhancing T-cell activity against the bacteria and also promoting tissue repair and regeneration. In addition to their effects on T cells, MSCs also interact with other immune cells, such as B cells and macrophages, which are involved in the immune response against Lyme disease. By regulating the activity of these different immune cells, MSCs help to promote an effective and targeted immune response against the bacteria, while also limiting tissue damage and promoting healing.
